White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

Cognitive reserve (CR) is a concept meant to account for the frequent discrepancy between
an individual's measured level of brain pathology and her expected cognitive performance. It …

Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …

Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged
Alzheimer's disease (AD) patients (n= 46). Patients with antemortem DTI studies and a …

Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …

The intervention at the stage of mild cognitive impairment (MCI) is promising for preventing
Alzheimer's disease (AD). This study aims to search for the optimal machine learning (ML) …

White matter microstructure undergoes progressive changes during the lifespan, but the
neurobiological underpinnings related to ageing and disease remains unclear. We used an …

Background White matter hyperintensities (WMH) are frequently found in Alzheimer's
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …

Objectives: The objective was to review the literature on diffusion tensor imaging as well as
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …

Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …