White matter hyperintensities, cognitive impairment and dementia: an update
ND Prins, P Scheltens - Nature Reviews Neurology, 2015 - nature.com
White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …
vessel disease, and can easily be detected on MRI. Over the past three decades, research …
Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve
Cognitive reserve (CR) is a concept meant to account for the frequent discrepancy between
an individual's measured level of brain pathology and her expected cognitive performance. It …
an individual's measured level of brain pathology and her expected cognitive performance. It …
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy
Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …
antibodies. To understand how proteins within these structures are arranged with nanoscale …
[HTML][HTML] White-matter integrity on DTI and the pathologic staging of Alzheimer's disease
Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged
Alzheimer's disease (AD) patients (n= 46). Patients with antemortem DTI studies and a …
Alzheimer's disease (AD) patients (n= 46). Patients with antemortem DTI studies and a …
[HTML][HTML] Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: a multimodal imaging investigation
AM Racine, N Adluru, AL Alexander, BT Christian… - NeuroImage: Clinical, 2014 - Elsevier
Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …
Searching for optimal machine learning model to classify mild cognitive impairment (MCI) subtypes using multimodal MRI data
T Jitsuishi, A Yamaguchi - Scientific Reports, 2022 - nature.com
The intervention at the stage of mild cognitive impairment (MCI) is promising for preventing
Alzheimer's disease (AD). This study aims to search for the optimal machine learning (ML) …
Alzheimer's disease (AD). This study aims to search for the optimal machine learning (ML) …
Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition
S Raghavan, RI Reid, SA Przybelski… - Brain …, 2021 - academic.oup.com
White matter microstructure undergoes progressive changes during the lifespan, but the
neurobiological underpinnings related to ageing and disease remains unclear. We used an …
neurobiological underpinnings related to ageing and disease remains unclear. We used an …
Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease
M Gaubert, C Lange, A Garnier-Crussard… - Alzheimer's Research & …, 2021 - Springer
Background White matter hyperintensities (WMH) are frequently found in Alzheimer's
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …
disease (AD). Commonly considered as a marker of cerebrovascular disease, regional …
Measuring cortical connectivity in Alzheimer's disease as a brain neural network pathology: toward clinical applications
Objectives: The objective was to review the literature on diffusion tensor imaging as well as
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …
Review of 'the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease'
TM Hughes, S Craft, OL Lopez - Neurodegenerative disease …, 2015 - Taylor & Francis
Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …