Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …

DNA DSBs (double-strand breaks) are considered the most cytotoxic type of DNA lesion.
They can be introduced by external sources such as IR (ionizing radiation), by …

The insertion of precise genetic modifications by genome editing tools such as CRISPR-
Cas9 is limited by the relatively low efficiency of homology-directed repair (HDR) compared …

Breakpoint junctions of the chromosomal translocations that occur in human cancers display
hallmarks of nonhomologous end-joining (NHEJ). In mouse cells, translocations are …

A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

To cope with DNA double strand break (DSB) genotoxicity, cells have evolved two main
repair pathways: homologous recombination which uses homologous DNA sequences as …

Non-homologous end-joining (NHEJ), the major repair pathway for DNA double-strand
breaks (DSB) in mammalian cells, employs a repertoire of core proteins, the recruitment of …

DNA double-strand breaks (DSBs) induced by ionizing radiation (IR) in cells of higher
eukaryotes are predominantly repaired by a pathway of non-homologous end joining …

Embryonic stem (ES) cells give rise to all cell types of an organism. Since mutations at this
embryonic stage would affect all cells and be detrimental to the overall health of an …

Nonhomologous end-joining represents the major pathway used by human cells to repair
DNA double-strand breaks. It relies on the XRCC4/DNA ligase IV complex to reseal DNA …