Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its
virulence is largely due to its polysaccharide capsule, which shields it from the host immune …

Capsular polysaccharides and exopolysaccharides play critical roles in bacterial survival
strategies, and they can have important medical and industrial applications. An immense …

Nasopharyngeal colonization is a necessary first step in the pathogenesis of Streptococcus
pneumoniae. Using isolates containing defined mutations in the S. pneumoniae capsule …

ABSTRACT CpsA, CpsB, CpsC, and CpsD are part of a tyrosine phosphorylation regulatory
system involved in modulation of capsule synthesis in Streptococcus pneumoniae and many …

Background Clostridium perfringens causes a range of diseases in animals and humans
including necrotic enteritis in chickens and food poisoning and gas gangrene in humans …

Tyrosine phosphorylation is associated with polysaccharide synthesis in a number of Gram-
positive and Gram-negative bacteria. In Streptococcus pneumoniae, CpsB, CpsC, and CpsD …

Extracellular polysaccharides of many bacteria are synthesized by the Wzy polymerase-
dependent mechanism, where long-chain polymers are assembled from undecaprenyl …

Synthesis of the type 3 capsular polysaccharide of Streptococcus pneumoniae requires UDP-
glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) for production of the [3)-β-d …

In this report, we show that biofilm formation by Streptococcus pneumoniae serotype 19
gives rise to variants (the small mucoid variant [SMV] and the acapsular small-colony variant …

The complete pneumococcal genome sequence was released in November, 1997. This
advance has been combined with new understanding of physiology and pathogenesis …