Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

Membrane proteins mediate many critical functions in cells. Determining their three-
dimensional structures in the native lipid environment has been one of the main objectives …

Water plays an essential role in the structure and function of proteins, lipid membranes and
other biological macromolecules. Solid-state NMR heteronuclear-detected 1 H polarization …

The microtubule-associated protein tau aggregates into distinct neurofibrillary tangles in
brains afflicted with multiple neurodegenerative diseases such as Alzheimer's disease and …

Heteronuclear cross polarization (CP) has been commonly used to enhance the sensitivity
of dilute low-γ nuclei in almost all solid-state NMR experiments. However, CP relies on …

We introduce an efficient approach for sequential protein backbone assignment based on
two complementary proton-detected 4D solid-state NMR experiments that correlate H _ i …

Membrane proteins are one of the most challenging and attractive objects in modern
structural biology, as they are targets for the majority of medicines. However, studies of …

Dynamic nuclear polarization (DNP) boosts the sensitivity of NMR spectroscopy by orders of
magnitude and makes investigations previously out of scope possible. For magic‐angle …

Solid-state nuclear magnetic resonance (NMR) is a potent tool for studying the structures
and dynamics of insoluble proteins. It starts with signal assignment through multi …