Animal models as a tool in hepatocellular carcinoma research: A Review

NP Santos, AA Colaco, PA Oliveira - Tumor Biology, 2017 - journals.sagepub.com
Cancer is the first cause of death in developed countries and the second in developing
countries. Concerning the most frequent worldwide-diagnosed cancer, primary liver cancer …

Cationic solid lipid nanoparticles of resveratrol for hepatocellular carcinoma treatment: systematic optimization, in vitro characterization and preclinical investigation

M Rahman, WH Almalki, O Afzal… - International Journal …, 2020 - Taylor & Francis
Aim The present study focuses on the development and evaluation of the resveratrol (RV)-
loaded cationic solid lipid nanoparticles (RV-c-SLNs) for the management of hepatocellular …

Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats

A Fahmi, N Hassanen, M Abdur-Rahman… - Biomarkers, 2019 - Taylor & Francis
Context: Chronic liver damage has serious medical consequences. Objective: To investigate
the hepatoprotective effect of dry Zingiber officinale (ginger) and its essential (volatile) oil …

Dual-ligand functionalized core-shell chitosan-based nanocarrier for hepatocellular carcinoma-targeted drug delivery

A Hefnawy, IH Khalil, K Arafa, M Emara… - International Journal …, 2020 - Taylor & Francis
Introduction Hepatocellular carcinoma represents a major health problem with the related
death numbers still increasing. Active targeting is considered an attractive choice for the …

Ameliorative effects of Aspergillus awamori against the initiation of hepatocarcinogenesis induced by diethylnitrosamine in a rat model: regulation of Cyp19 and p53 …

DH Assar, AAA Mokhbatly, EW Ghazy, AE Ragab… - Antioxidants, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common cancer in humans. Despite advances
in its treatment, liver cancer remains one of the most difficult cancers to treat. This study …

[HTML][HTML] Effects of Echinacea purpurea on hepatic and renal toxicity induced by diethylnitrosamine in rats

A Rezaie, A Fazlara, MH Karamolah… - … journal of natural …, 2013 - ncbi.nlm.nih.gov
Background Nitrites are mainly used in food preservation. These materials could change to
nitrosamine due to the effect of heat and gastric acid. Nitrosamine is absorbed in intestine …

[HTML][HTML] Chemoprotective effect of Elettaria cardamomum against chemically induced hepatocellular carcinoma in rats by inhibiting NF-κB, oxidative stress, and activity …

NM Elguindy, GA Yacout, EF El Azab… - South African journal of …, 2016 - Elsevier
The chemoprotective effect of Elettaria cardamomum (cardamom) extract was studied
against DENA (200 mg/kg) induced hepatocellular carcinoma (HCC) in comparison to the …

[HTML][HTML] The carcinogenic agent diethylnitrosamine induces early oxidative stress, inflammation and proliferation in rat liver, stomach and colon: protective effect of …

DF Mansour, HMI Abdallah, BMM Ibrahim… - Asian Pacific journal …, 2019 - ncbi.nlm.nih.gov
Background: Diethylnitrosamine (DENA), a well-known dietary carcinogen, related to cancer
initiation of various organs. The present study investigated the deleterious mechanisms …

[HTML][HTML] Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents

D Singh, D Chaudhary, V Kumar, A Verma - Toxicology Reports, 2021 - Elsevier
Introduction Inflammation and oxidative stress are the main factors ascribed with interruption
in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well …

Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats

J Song, W Ding, B Liu, D Liu, Z Xia… - Molecular …, 2020 - spandidos-publications.com
An overwhelming endoplasmic reticulum stress (ERS) and the following unfolded protein
response (UPR) can induce hepatic inflammation, fibrosis and hepatocellular carcinoma …