Abstract N6-methyladenosine (m6A) is the most abundant mRNA modification. With the
development of antibody-based sequencing technologies and the findings of m6A-related …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Nuclear shape and architecture influence gene localization, mechanotransduction,
transcription, and cell function. Abnormal nuclear morphology and protrusions termed …

Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5,
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with
small molecules both for the generation of probes for target exploration and for therapeutic …