Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

Nuclei move to specific locations to polarize migrating and differentiating cells. Many nuclear
movements are microtubule-dependent. However, nuclear movement to reorient the …

Nuclear movement is critical during neurogenesis and neuronal migration, which are
fundamental for mammalian brain development. Although dynein, Lis1, and other …

Notch signaling has been shown over the past few decades to play fundamental roles in a
plethora of developmental processes in an evolutionarily conserved fashion. Notch …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

The Notch pathway is prominent among those known to regulate neural development in
vertebrates. Notch receptor activation can inhibit neurogenesis, maintain neural progenitor …