The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α2‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas
and contributes to the failure of current therapeutic modalities (surgery, radiation and …

Necrosis and vascular proliferation are the pathologic features that distinguish the most
malignant infiltrative astrocytoma, glioblastoma (GBM), from those of lower grades. In GBM …

Cutaneous melanoma is a highly invasive and metastatic tumor. Degradation of basement
membranes and extracellular matrix is an essential step in melanoma cell migration …

Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

T HE PLASMINOGEN activator (PA) system is responsi-ble for the degradation of
intravascular blood clots,'while also contributing to extracellular proteolysis in a wide variety …

Expression of hepatocyte growth factor (HGF) and HGF receptor (HGFR, product of the met
proto-oncogene) mRNA were examined by nonisotopic in situ hybridization in a spectrum of …

Hypoxia activates genetic programs that facilitate cell survival; however, in cancer, it may
promote invasion and metastasis. In this study, we show that breast cancer cells cultured in …