During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

Glucocorticoids are potent immunosuppressive agents with complex actions on immune
cells evoking the following effects: inducing apoptosis, changing differentiation fate …

Background & Aims Bile acids (BAs) are major regulators of hepatic BA and lipid metabolism
but their mechanisms of action in non-alcoholic fatty liver disease (NAFLD) are still poorly …

Glucocorticoids (GCs) are a class of steroid hormones which regulate a variety of essential
biological functions. The profound anti-inflammatory and immunosuppressive activity of …

Glucocorticoids (GCs) are widely used in the treatment of allergic skin conditions despite
having numerous side effects. Here we use Cre/loxP-engineered tissue-and cell-specific …

Abstract Coronavirus Disease 19 (COVID-19) is associated with high morbidity and mortality
rates globally, representing the greatest health and economic challenge today. Several …

Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …

Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of
many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by …

An established body of knowledge and clinical practice has argued in favor of the use of
glucocorticoids in various chronic inflammatory and autoimmune diseases. However, the …

Acetylation of signaling molecules can lead to apoptosis or differentiation of carcinoma cells.
The molecular mechanisms underlying these processes and the biological role of enzymes …