Natural products inhibitors of monoamine oxidases—Potential new drug leads for neuroprotection, neurological disorders, and neuroblastoma

ND Chaurasiya, F Leon, I Muhammad, BL Tekwani - Molecules, 2022 - mdpi.com
Monoamine oxidase inhibitors (MAOIs) are an important class of drugs prescribed for
treatment of depression and other neurological disorders. Evidence has suggested that …

Neuroprotective function of rasagiline and selegiline, inhibitors of type B monoamine oxidase, and role of monoamine oxidases in synucleinopathies

M Naoi, W Maruyama, M Shamoto-Nagai - International Journal of …, 2022 - mdpi.com
Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation
of toxic species of α-synuclein. The common clinical features are chronic progressive …

Mitochondrial-targeted and near-infrared fluorescence probe for bioimaging and evaluating monoamine oxidase A activity in hepatic fibrosis

ZM Yang, QY Mo, JM He, DL Mo, J Li, H Chen… - ACS …, 2020 - ACS Publications
Monoamine oxidase A (MAO-A) is a promising diagnostic marker for cancer, depression,
Parkinson's disease, and liver disease. The fluorescence detection of MAO-A in living …

Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model

R Mondal, C Banerjee, S Nandy, M Roy… - Cell & Bioscience, 2023 - Springer
Background Parkinson's disease (PD), a highly prevalent neuro-motor disorder is caused
due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of …

Myricitrin–a flavonoid isolated from the Indian olive tree (Elaeocarpus floribundus)–inhibits Monoamine oxidase in the brain and elevates striatal dopamine levels …

C Banerjee, S Nandy, J Chakraborty, D Kumar - Food & Function, 2022 - pubs.rsc.org
Flavonoids exhibit several biological activities including inhibition of Monoamine oxidase
(MAO), an enzyme that metabolizes several neurotransmitters. Thus, MAO inhibitors are well …

Monoamine oxidase-dependent pro-survival signaling in diabetic hearts is mediated by miRNAs

S Cagnin, M Brugnaro, C Millino, B Pacchioni… - Cells, 2022 - mdpi.com
Diabetes leads to cardiomyopathy and heart failure, the leading cause of death for diabetic
patients. Monoamine oxidase (MAO) inhibition in diabetic cardiomyopathy prevents …

Induction of monoamine oxidase A-mediated oxidative stress and impairment of NRF2-antioxidant defence response by polyphenol-rich fraction of Bergenia ligulata …

S Ghosh, N Dutta, P Banerjee, RL Gajbhiye… - Free Radical Biology …, 2021 - Elsevier
Prostate cancer (PCa) is a major cause of mortality and morbidity in men. Available
therapies yield limited outcome. We explored anti-PCa activity in a polyphenol-rich fraction …

Recent advances on the role of monoamine oxidases in cardiac pathophysiology

N Kaludercic, RJ Arusei, F Di Lisa - Basic Research in Cardiology, 2023 - Springer
Numerous physiological and pathological roles have been attributed to the formation of
mitochondrial reactive oxygen species (ROS). However, the individual contribution of …

IL-13 and the hydroperoxy fatty acid 13 (S) HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis

P Biswas, S Swaroop, N Dutta, A Arya, S Ghosh… - Free Radical Biology …, 2023 - Elsevier
This study depicted the effect of IL-13 and 13 (S) HpODE (the endogenous product during IL-
13 activation) in the process of cancer cell apoptosis. We examined the role of both IL-13 …

Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease

M Naoi, W Maruyama, M Shamoto-Nagai… - Journal of Neural …, 2024 - Springer
Parkinson's disease is characterized by its distinct pathological features; loss of dopamine
neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy …