Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

C Chen, J Liao, Y Xia, X Liu, R Jones, J Haran… - Gut, 2022 - gut.bmj.com
Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …

Network abnormalities and interneuron dysfunction in Alzheimer disease

JJ Palop, L Mucke - Nature Reviews Neuroscience, 2016 - nature.com
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

The mucosal immune system of teleost fish

I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

SJ Webster, AD Bachstetter, PT Nelson… - Frontiers in …, 2014 - frontiersin.org
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

[HTML][HTML] Alzheimer mechanisms and therapeutic strategies

Y Huang, L Mucke - Cell, 2012 - cell.com
There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Neurotoxicity of amyloid β-protein: synaptic and network dysfunction

L Mucke, DJ Selkoe - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Evidence for an ever-expanding variety of molecular mediators of amyloid β-protein
neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers …

The essentiality of arachidonic acid in infant development

KB Hadley, AS Ryan, S Forsyth, S Gautier, N Salem Jr - Nutrients, 2016 - mdpi.com
Arachidonic acid (ARA, 20: 4 n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by
the biosynthesis from linoleic acid (LA, 18: 2 n-6). This review considers the essential role …