Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia

S Anguille, VF Van Tendeloo, ZN Berneman - Leukemia, 2012 - nature.com
The graft-versus-leukemia effect of allogeneic hematopoietic stem cell transplantation
(HSCT) has shown that the immune system is capable of eradicating acute myeloid …

Graft-versus-host disease versus graft-versus-leukemia

RS Negrin - Hematology 2014, the American Society of …, 2015 - ashpublications.org
Graft-versus-host disease (GVHD) is a significant clinical problem after allogenic
hematopoietic cell transplantation (HCT) associated with substantial morbidity and mortality …

Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1

ZG Gulzar, JK McKenney, JD Brooks - Oncogene, 2013 - nature.com
Increasing evidence suggests that prostate cancer is overdiagnosed and overtreated, and
prognostic biomarkers would aid in treatment selection. To define prognostic biomarkers for …

[HTML][HTML] NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity

C Li, Y Zhang, Q Yang, F Ye, SY Sun, ES Chen… - Scientific reports, 2016 - nature.com
Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that
functions as a microtubule stabiliser. Depletion of NuSAP leads to severe mitotic defects …

Dose escalation of lenalidomide in relapsed or refractory acute leukemias

W Blum, RB Klisovic, H Becker, X Yang… - Journal of clinical …, 2010 - ascopubs.org
Purpose Lenalidomide is effective in myeloma and low-risk myelodysplastic syndromes with
deletion 5q. We report results of a phase I dose-escalation trial of lenalidomide in relapsed …

High NUSAP1 expression predicts poor prognosis in colon cancer

Z Liu, C Guan, C Lu, Y Liu, R Ni, M Xiao… - Pathology-Research and …, 2018 - Elsevier
Background and aim Nucleolar and spindle-associated protein 1 (NUSAP1) is an
indispensable mitotic regulator. Aberrant NUSAP1 expression is associated with perturbed …

The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease

A Volk, JD Crispino - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2015 - Elsevier
Nucleosome assembly following DNA synthesis is critical for maintaining genomic stability.
The proteins directly responsible for shuttling newly synthesized histones H3 and H4 from …

[HTML][HTML] Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway

X Wu, B Xu, C Yang, W Wang, D Zhong, Z Zhao… - Journal of Experimental …, 2017 - Springer
Background The prognosis of human astrocytoma is poor, and the molecular alterations
underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated …

NUSAP1 expression is upregulated by loss of RB1 in prostate cancer cells

CA Gordon, ZG Gulzar, JD Brooks - The Prostate, 2015 - Wiley Online Library
BACKGROUND Overexpression of NUSAP1 is associated with poor prognosis in prostate
cancer, but little is known about what leads to its overexpression. Based on previous …

[HTML][HTML] T cell optimization for graft-versus-leukemia responses

MA Biernacki, VS Sheth, M Bleakley - JCI insight, 2020 - ncbi.nlm.nih.gov
Protection from relapse after allogeneic hematopoietic cell transplantation (HCT) is partly
due to donor T cell–mediated graft-versus-leukemia (GVL) immune responses. Relapse …