SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but
the reasons for this are not fully understood. More efficient local tissue responses, better …

Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

We present an interim analysis of a registered clinical study (NCT04800133) to establish
immunobridging with various antibody and cellular immunity markers and to compare the …

Coronavirus disease 2019 in children presents with milder clinical manifestations than in
adults. On the other hand, the presence of a wide range of inflammatory manifestations …

A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …

Background Individuals with primary and secondary immunodeficiency (PID/SID) were
shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic …

Morbidity and mortality of COVID-19 is increased in patients with inborn errors of immunity
(IEI). Age and comorbidities and also impaired type I interferon immunity were identified as …

COVID-19 manifestations range from asymptomatic to life-threatening infections. The
outcome in different inborn errors of immunity (IEI) is still a matter of debate. In this …

Background Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected
individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the …