The increasing emergence of antimicrobial-resistant organisms, especially methicillin-
resistant Staphylococcus aureus (MRSA), has resulted in the increased use of rifampin …

Access to antiretroviral therapy is rapidly expanding in resource-limited settings, where
tuberculosis is the most common opportunistic infection. Coadministration of antitubercular …

WHO has proposed a public-health approach to antiretroviral therapy (ART) to enable
scaling-up access to treatment for HIV-positive people in developing countries, recognising …

Context Rifampicin-based antitubercular therapy reduces the plasma concentrations of
nevirapine and efavirenz. The virological consequences of these interactions are not well …

Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality
among HIV-infected patients, especially in resource-limited countries. Clinical …

CYP2B6 is mainly expressed in the liver that has been thought historically to play an
insignificant role in human drug metabolism. However, increased interest in this enzyme has …

Worldwide, it is estimated that 14.8% of all new TB cases in adults are attributable to HIV
infection. This proportion is much greater in Africa, where 79% of all TB/HIV coinfections are …

Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes as well as the P-
glycoprotein transport system. Several examples of well-documented clinically significant …

Background The aim of this study was to examine factors influencing plasma concentration
of efavirenz and nevirapine. Methods Data from the Liverpool Therapeutic Drug Monitoring …

Human immunodeficiency virus/acquired immune-deficiency syndrome (HIV/AIDS) and
tuberculosis (TB) are overlapping epidemics that cause an immense burden of disease in …