Urine biomarkers in bladder cancer—Current status and future perspectives

M Maas, T Todenhöfer, PC Black - Nature Reviews Urology, 2023 - nature.com
Urine markers to detect bladder cancer have been the subject of research for decades. The
idea that urine—being in continuous contact with tumour tissue—should provide a vector of …

Revisiting hematopoiesis: applications of the bulk and single-cell transcriptomics dissecting transcriptional heterogeneity in hematopoietic stem cells

I Monga, K Kaur, SK Dhanda - Briefings in functional genomics, 2022 - academic.oup.com
Hematopoietic system (HS) is one of the most unique, adaptive and comprehensive
developmental systems on which various other body systems relies on. It consists of a …

[HTML][HTML] Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

J Qadir, F Li, BB Yang - Theranostics, 2022 - ncbi.nlm.nih.gov
The Hippo signaling pathway is an evolutionarily conserved network that regulates organ
size and tissue homeostasis in mammals. This pathway controls various cell functions, such …

Circular RNA circRIMS1 acts as a sponge of miR-433-3p to promote bladder cancer progression by regulating CCAR1 expression

F Wang, M Fan, Y Cai, X Zhou, S Tai, Y Yu… - … Therapy-Nucleic Acids, 2020 - cell.com
Circular RNAs (circRNAs), a subclass of noncoding RNAs, are reportedly involved in the
progression of various diseases. However, the exact role of circRIMS1, also termed …

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Y Zeng, A Wang, W Lv, Q Wang, S Jiang… - Clinical and …, 2023 - Wiley Online Library
Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early
screening and diagnosis of bladder cancer. This review provides a comprehensive overview …

The role of circular RNAs in DNA damage response and repair

A Papaspyropoulos, O Hazapis, N Lagopati, A Polyzou… - Cancers, 2021 - mdpi.com
Simple Summary The role of non-coding RNA, and particularly of circular RNA, in the DNA
damage response and repair network is underappreciated. Given the vital role of this …

[HTML][HTML] Trends in urine biomarker discovery for urothelial bladder cancer: DNA, RNA, or protein?

N Humayun-Zakaria, DG Ward, R Arnold… - Translational …, 2021 - ncbi.nlm.nih.gov
Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous
molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance …

Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical …

A Goel, DG Ward, B Noyvert, M Yu, NS Gordon… - Genome medicine, 2022 - Springer
Background Three-quarters of bladder cancer patients present with early-stage disease
(non-muscle-invasive bladder cancer, NMIBC, UICC TNM stages Ta, T1 and Tis); however …

Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-κB and CREB signaling in a bile duct ligation mouse model: transcriptional …

D Jo, YH Lim, YS Jung, YK Kim, J Song - Journal of Neuroinflammation, 2023 - Springer
Background Hepatic encephalopathy-induced hyperammonemia alters astrocytic glutamate
metabolism in the brain, which is involved in cognitive decline. To identify specific …

[HTML][HTML] Advanced strategies of targeting circular RNAs as therapeutic approaches in colorectal cancer drug resistance

BM Hussen, SR Abdullah, AA Mohammed… - … -Research and Practice, 2024 - Elsevier
Colorectal cancer (CRC) stands second in terms of mortality and third among the highest
prevalent kinds of cancer globally. CRC prevalence is rising in moderately and poorly …