Hereditary breast and ovarian cancer: new genes in confined pathways
FC Nielsen, T van Overeem Hansen… - Nature Reviews …, 2016 - nature.com
Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …
breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC …
Molecular classification of breast cancer
D Vuong, PT Simpson, B Green, MC Cummings… - Virchows Archiv, 2014 - Springer
Breast cancer is a complex, multifaceted disease encompassing a great variety of entities
that show considerable variation in clinical, morphological and molecular attributes …
that show considerable variation in clinical, morphological and molecular attributes …
Sublethal cytochrome c release generates drug-tolerant persister cells
Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome
interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative …
interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative …
A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome
P Soret, C Le Dantec, E Desvaux, N Foulquier… - Nature …, 2021 - nature.com
There is currently no approved treatment for primary Sjögren's syndrome, a disease that
primarily affects adult women. The difficulty in developing effective therapies is-in part …
primarily affects adult women. The difficulty in developing effective therapies is-in part …
Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value
Background Colon cancer (CC) pathological staging fails to accurately predict recurrence,
and to date, no gene expression signature has proven reliable for prognosis stratification in …
and to date, no gene expression signature has proven reliable for prognosis stratification in …
[HTML][HTML] Prognostic and predictive value of PDL1 expression in breast cancer
Expression of programmed cell death receptor ligand 1 (PDL1) has been scarcely studied in
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
breast cancer. Recently PD1/PDL1-inhibitors have shown promising results in different …
[HTML][HTML] A phase II trial of abiraterone acetate plus prednisone in patients with triple-negative androgen receptor positive locally advanced or metastatic breast cancer …
H Bonnefoi, T Grellety, O Tredan, M Saghatchian… - Annals of …, 2016 - Elsevier
Background Several expression array studies identified molecular apocrine breast cancer
(BC) as a subtype that expresses androgen receptor (AR) but not estrogen receptor α. We …
(BC) as a subtype that expresses androgen receptor (AR) but not estrogen receptor α. We …
[HTML][HTML] Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …
development and progression. While many of the different MMPs expressed in breast cancer …
Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
DR Cochrane, S Bernales, BM Jacobsen… - Breast Cancer …, 2014 - Springer
Introduction The androgen receptor (AR) is widely expressed in breast cancers and has
been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast …
been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast …