It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

Bladder cancer is one of the most common malignancies in the world. Cisplatin is one of the
most potent and widely used anticancer drugs and has been employed in several …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …