Brain lipidomics as a rising field in neurodegenerative contexts: Perspectives with Machine Learning approaches
DB Castellanos, CA Martín-Jiménez… - Frontiers in …, 2021 - Elsevier
Lipids are essential for cellular functioning considering their role in membrane composition,
signaling, and energy metabolism. The brain is the second most abundant organ in terms of …
signaling, and energy metabolism. The brain is the second most abundant organ in terms of …
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia
The E4 allele of the apolipoprotein E gene (APOE) has been established as a genetic risk
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
factor for many diseases including cardiovascular diseases and Alzheimer's disease (AD) …
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
OC Kwon, JJ Song, Y Yang, SH Kim, JY Kim… - EMBO molecular …, 2021 - embopress.org
Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory
environments in disease contexts and thereby contribute to the progression of neuronal loss …
environments in disease contexts and thereby contribute to the progression of neuronal loss …
Neuron‐glia (mis) interactions in brain energy metabolism during aging
G Mayorga‐Weber, FJ Rivera… - Journal of Neuroscience …, 2022 - Wiley Online Library
Life expectancy in humans is increasing, resulting in a growing aging population, that is
accompanied by an increased disposition to develop cognitive deterioration …
accompanied by an increased disposition to develop cognitive deterioration …
Characterizing macrophage diversity in metastasis-bearing lungs reveals a lipid-associated macrophage subset
While macrophages are among the most abundant immune cell type found within primary
and metastatic mammary tumors, how their complexity and heterogeneity change with …
and metastatic mammary tumors, how their complexity and heterogeneity change with …
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic
variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and …
variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and …
[HTML][HTML] Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder
K Skorobogatov, V Autier, M Foiselle… - Brain, Behavior, & …, 2023 - Elsevier
Schizophrenia (SCZ) and bipolar disorder (BD) are associated with immunological
dysfunctions that have been hypothesized to lead to clinical symptomatology in particular …
dysfunctions that have been hypothesized to lead to clinical symptomatology in particular …
[HTML][HTML] Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives
Glia, which was formerly considered to exist just to connect neurons, now plays a key
function in a wide range of physiological events, including formation of memory, learning …
function in a wide range of physiological events, including formation of memory, learning …
Pharmacological upregulation of microglial lipid droplet alleviates neuroinflammation and acute ischemic brain injury
H Li, P Liu, S Deng, L Zhu, X Cao, X Bao, S Xia, Y Xu… - Inflammation, 2023 - Springer
Lipid droplets (LDs) were reported to play an important role in the modulation of
inflammation and various cellular processes among multiple cell types. However, LDs …
inflammation and various cellular processes among multiple cell types. However, LDs …