Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …

For industrial production of recombinant protein biopharmaceuticals, Chinese hamster ovary
(CHO) cells represent the most widely adopted host cell system, owing to their capacity to …

There are numerous applications for recombinant antibodies (rAbs) in biological and
toxicological research. Monoclonal antibodies are synthesized using genetic engineering …

Chinese hamster ovary (CHO) cells have been routinely used as a factory for recombinant
proteins for several years, and their improvements have been the focus of consideration …

At present, approximately 80% of the currently approved recombinant therapeutic proteins
are produced by Chinese hamster ovary cells. However, considering that the human …

Nowadays, a significant part of the investigations carried out in the medical field belong to
cancer treatment. Generally, conventional cancer treatments, including chemotherapy …

Acute kidney injury (AKI) is a major problem in bedridden patients or in platinum-based
chemotherapy patients. This disease is linked with elevated morbidity and mortality …

Two genome editions have resulted in the CHO cell line 4BGD with homozygous knockouts
of the BAK1, BAX, DHFR and GLUL genes, and overexpression of the BCL2 and BECN1 …

Background: CHO cells are preferred for producing biopharmaceuticals, and genome
editing technologies offer opportunities to enhance recombinant protein production …

Mémoire présenté à la Faculté de médecine et des sciences de la santé en vue de
l'obtention du diplôme de maitre ès sciences (M. Sc.) en pharmacologie, Faculté de …