Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …

Phosphorylation is the most common post-translational modification (PTM) in eukaryotes,
occurring particularly frequently in intrinsically disordered proteins (IDPs). These proteins …

Drug resistance is a serious impediment to the treatment of cancer. However, the
mechanisms involved remain poorly understood. While it is widely held that the …

There is mounting evidence that Alzheimer's disease progression and severity are linked to
neuronal membrane damage caused by aggregates of the amyloid-β (A β) peptide …

Highlights•SAXS captures architecture and dynamics to elucidate molecular
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …

It is well known that genetic mutations can drive drug resistance and lead to tumor relapse.
Here, we focus on alternate mechanisms—those without mutations, such as phenotypic …

Protein kinases represent a very pharmacologically attractive class of targets; however,
some members of the family still remain rather unexplored. The biology and therapeutic …

A good portion of the 'protein universe'embodies the 'dark proteome'. The latter comprises
proteins not amenable to experimental structure determination by existing means and …

Several transcription factor (TF) families, including the MYB family, regulate a wide array of
biological processes. TFs contain DNA-binding domains (DBDs) and regulatory regions; …