Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

The central amygdala (CeA) plays a central role in physiologic and behavioral responses to
fearful stimuli, stressful stimuli, and drug-related stimuli. The CeA receives dense inputs from …

In the past 20 years we have learned a great deal about GABA A receptor (GABA AR)
subtypes, and which behaviors are regulated or which drug effects are mediated by each …

Aversive experiences can lead to complex behavioral adaptations including increased
levels of anxiety and fear generalization. The neuronal mechanisms underlying such …

The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations
during subunit assembly give rise to a variety of receptors with different functional properties …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

With rapid aging of the population worldwide, the number of people with dementia is
dramatically increasing. Some studies have emphasized that metabolic syndrome, which …

Regulation of hypothalamic–pituitary–adrenocortical (HPA) axis activity by stress is a
fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders …