Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Atherosclerotic plaque healing

R Vergallo, F Crea - New England journal of medicine, 2020 - Mass Medical Soc
Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association

JF Meschia, C Bushnell, B Boden-Albala, LT Braun… - Stroke, 2014 - Am Heart Assoc
The aim of this updated statement is to provide comprehensive and timely evidence-based
recommendations on the prevention of stroke among individuals who have not previously …

Application of light scattering techniques to nanoparticle characterization and development

PM Carvalho, MR Felício, NC Santos… - Frontiers in …, 2018 - frontiersin.org
Over the years, the scientific importance of nanoparticles for biomedical applications has
increased. The high stability and biocompatibility, together with the low toxicity of the …

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

EM Maguire, SWA Pearce, Q Xiao - Vascular Pharmacology, 2019 - Elsevier
During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Mechanisms of acute coronary syndromes and their implications for therapy

P Libby - New England Journal of Medicine, 2013 - Mass Medical Soc
The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …

Imaging macrophages with nanoparticles

R Weissleder, M Nahrendorf, MJ Pittet - Nature materials, 2014 - nature.com
Nanomaterials have much to offer, not only in deciphering innate immune cell biology and
tracking cells, but also in advancing personalized clinical care by providing diagnostic and …

Towards clinically translatable in vivo nanodiagnostics

S Park, A Aalipour, O Vermesh, JH Yu… - Nature Reviews …, 2017 - nature.com
Nanodiagnostics as a field makes use of fundamental advances in nanobiotechnology to
diagnose, characterize and manage disease at the molecular scale. As these strategies …

2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart …

P Greenland, JS Alpert, GA Beller, EJ Benjamin… - Journal of the American …, 2010 - jacc.org
The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted for the period beginning March 2008 through …