Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

K Pitt, R Peña, JD Tew, K Pal, R Smith, ZK Nagy… - Powder Technology, 2018 - Elsevier
Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …

Spherical crystallization of drugs

B Kovačič, F Vrečer, O Planinšek - Acta pharmaceutica, 2012 - sciendo.com
Spherical crystallization of drugs is the process of obtaining larger particles by
agglomeration during crystallization. The most common techniques used to obtain such …

Design of the spherical agglomerate size in crystallization by developing a two‐step bridging mechanism and the model

C Yu, M Yao, Y Ma, Y Liu, S Guo, S Xu… - AIChE …, 2022 - Wiley Online Library
Spherical agglomeration technology can produce high‐performance spherical particles in a
single crystallization unit, although it is still challenging to control the particle size and …

Spherical agglomerates of lactose with enhanced mechanical properties

D Lamešić, O Planinšek, Z Lavrič, I Ilić - International journal of …, 2017 - Elsevier
The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their
physicochemical properties, flow properties, particle friability and compaction properties …

Further understanding of agglomeration mechanisms in spherical crystallization systems: benzoic acid case study

R Peña, DJ Jarmer, CL Burcham… - Crystal Growth & …, 2019 - ACS Publications
Spherical crystallization is a particle size enlargement technique that can provide significant
process and micromeritic benefits to the production of active pharmaceutical ingredients. To …

Preparation and Characterization of Co-Grinded Mixtures of Aceclofenac and Neusilin US2 for Dissolution Enhancement of Aceclofenac

AH Vadher, JR Parikh, RH Parikh, AB Solanki - Aaps Pharmscitech, 2009 - Springer
The present study was carried out with a view to enhance the dissolution of poorly water-
soluble BCS-class II drug aceclofenac by co-grinding with novel porous carrier Neusilin US …

Continuous spherical crystallization of lysozyme in an oscillatory baffled crystallizer using emulsion solvent diffusion in droplets

JA Oliva, WL Wu, MR Greene, K Pal… - Crystal Growth & …, 2020 - ACS Publications
Continuous protein crystallization is a cost-effective alternative to traditional
chromatographic purification techniques. However, proteins characteristically have slow …

Crystal engineering for enhanced solubility and bioavailability of poorly soluble drugs

J Varshosaz, E Ghassami… - Current pharmaceutical …, 2018 - ingentaconnect.com
Background: Crystal engineering is dealing with the creation of new structures and new
properties in drug molecules through inter-molecular interactions. Researchers of …

Chitosan cocrystals embedded alginate beads for enhancing the solubility and bioavailability of aceclofenac

M Ganesh, UJ Jeon, U Ubaidulla, P Hemalatha… - International journal of …, 2015 - Elsevier
Enhanced oral bioavailability of aceclofenac has been achieved using chitosan cocrystals of
aceclofenac and its entrapment into alginate matrix a super saturated drug delivery system …

A top-down technique to improve the solubility and bioavailability of aceclofenac: in vitro and in vivo studies

R Narayan, A Pednekar, D Bhuyan… - International journal …, 2017 - Taylor & Francis
The aim of the present work was to tackle the solubility issue of a biopharmaceutics
classification system (BCS)-II drug, aceclofenac. Although a number of attempts to increase …