[HTML][HTML] Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives

G Liu, J Wei, W Xiao, W Xie, Q Ru, L Chen, Y Wu… - Biomedicine & …, 2023 - Elsevier
Degenerative musculoskeletal disorders are a group of age-related diseases of the
locomotive system that severely affects the patient's ability to work and cause adverse …

Why Does Rehabilitation Not (Always) Work in Osteoarthritis? Does Rehabilitation Need Molecular Biology?

A Zdziechowski, A Gluba-Sagr, J Rysz… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a common disease among the human population worldwide. OA
causes functional impairment, leads to disability and poses serious socioeconomic burden …

The Role of Selenium-Mediated Notch/Hes1 Signaling Pathway in Kashin–Beck Disease Patients and Cartilage Injury Models

D Zhang, D Zhang, X Yang, Q Li, R Zhang… - … Trace Element Research, 2023 - Springer
Kashin–Beck disease (KBD) is a nutrition-related osteoarthropathy, and selenium (Se)
deficiency is an environmental risk factor for KBD. Notch/Hes1 signaling pathway plays a …

[HTML][HTML] Notch4 affects the proliferation and differentiation of deer antler chondrocytes through the Smad3/lncRNA27785. 1 axis

DY Chen, M Yang, ZT Sun, M Song, HB Yao, G Long… - Cellular …, 2022 - Elsevier
Long non-coding RNA play an importantr role in the differentiation of chondrocytes. This
study aims to explore the role of long non-coding RNA in the transcriptional regulation of …

NOTCH1: A Novel Player in the Molecular Crosstalk Underlying Articular Chondrocyte Protection by Oleuropein and Hydroxytyrosol

V Panichi, I Bissoli, S D'Adamo, F Flamigni… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is the most common joint disease, but no effective and safe disease-
modifying treatment is available. Risk factors such as age, sex, genetics, injuries and obesity …

The study on bone marrow mesenchymal stem cell-derived extracellular matrix promoting the repair of damaged chondrocytes by regulating the Notch1/RBPJ …

J Huang, N Zeng, S Xu, Y Lv, X Li, P Yang, Y Liu - Cytotechnology, 2025 - Springer
Cartilage and joint damage can lead to cartilage degeneration. Bone marrow mesenchymal
stem cells (BMSCs) have the potential to address cartilage damage. Hence, this study …

细胞因子治疗骨关节炎的研究现状及应用前景

张克凡, 石辉 - 中国组织工程研究, 2024 - cjter.com
细胞因子治疗骨关节炎的研究现状及应用前景 Page 1 Chinese Journal of Tissue Engineering
Research|Vol 28|No.6|February 2024|961 中国组织工程研究 Chinese Journal of Tissue …

Determining the Notch1 Expression in Chondrogenically Differentiated Rat Amniotic Fluid Stem Cells in Alginate Beads Using Conditioned Media from Chondrocytes …

ÖÖ Akkaya, S Nawaz, T Dikmen, M Erdoğan - Biology Bulletin, 2022 - Springer
The molecular mechanisms involved in the progression of chondrogenic differentiation
require considerable studies, despite significant advancement in recent years …

Protective effects of ginseng and ginsenosides in the development of osteoarthritis

J Chen, L Huang, X Liao - … and Therapeutic Medicine, 2023 - spandidos-publications.com
Osteoarthritis (OA) is a chronic inflammatory joint disease. Traditional chinese medicine
provides a resource for drug screening for OA treatment. Ginseng and the associated …

Melatonin promotes the proliferation and differentiation of antler chondrocytes via RUNX2 dependent on the interaction between NOTCH1 and SHH signaling …

Q Zhang, Y Zhang, B Li, C Wang, Z Yang… - Cell Biology … - Wiley Online Library
Melatonin (MT), an endogenous hormone secreted by pineal gland, has the sedative, anti‐
inflammatory and antioxidant functions. However, there are few studies on whether MT …