BDNF as a promising therapeutic agent in Parkinson's disease

E Palasz, A Wysocka, A Gasiorowska… - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Adolescent alcohol exposure persistently impacts adult neurobiology and behavior

FT Crews, RP Vetreno, MA Broadwater… - Pharmacological …, 2016 - Elsevier
Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

High rate of recurrent de novo mutations in developmental and epileptic encephalopathies

FF Hamdan, CT Myers, P Cossette, P Lemay… - The American Journal of …, 2017 - cell.com
Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized
by the co-occurrence of epilepsy and intellectual disability (ID), typically with developmental …

Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials

J Houlton, N Abumaria, SFR Hinkley… - Frontiers in …, 2019 - frontiersin.org
Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

SJ Tsai - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …

Sex differences in fear extinction

ER Velasco, A Florido, MR Milad, R Andero - … & Biobehavioral Reviews, 2019 - Elsevier
Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …

BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges

B Thakkar, EO Acevedo - Brain and Behavior, 2023 - Wiley Online Library
Introduction The primary objective of this paper is to (1) provide a summary of human studies
that have used brain derived neurotrophic factor (BDNF) as a biomarker,(2) review animal …

Corticostriatal BDNF and alcohol addiction

ML Logrip, S Barak, V Warnault, D Ron - Brain research, 2015 - Elsevier
Growth factors, long studied for their involvement in neuronal development and plasticity,
also regulate responses to drugs of abuse, including alcohol. This review details the intricate …

The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus

OF O'Leary, ES Ogbonnaya, D Felice… - European …, 2018 - Elsevier
Accumulating evidence suggests that certain gut microbiota have antidepressant-like
behavioural effects and that the microbiota can regulate neurogenesis and the expression of …