Electrophysiology read-out tools for brain-on-chip biotechnology

C Forro, D Caron, GN Angotzi, V Gallo, L Berdondini… - Micromachines, 2021 - mdpi.com
Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …

Recent progress in voltage-sensitive dye imaging for neuroscience

V Tsytsarev, LD Liao, KV Kong, YH Liu… - … of nanoscience and …, 2014 - ingentaconnect.com
Voltage-sensitive dye imaging (VSDi) enables visualization of information processing in
different areas of the brain with reasonable spatial and temporal resolution. VSDi employs …

All-optical detection of neuronal membrane depolarization in live cells using colloidal quantum dots

M Caglar, R Pandya, J Xiao, SK Foster, G Divitini… - Nano …, 2019 - ACS Publications
Luminescent semiconductor quantum dots (QDs) have recently been suggested as novel
probes for imaging and sensing cell membrane voltages. However, a key bottleneck for their …

Improved surface functionalization and characterization of membrane-targeted semiconductor voltage nanosensors

J Park, Y Kuo, J Li, YL Huang, EW Miller… - The Journal of …, 2019 - ACS Publications
Type-II ZnSe/CdS voltage-sensing seeded nanorods (vsNRs) were functionalized with α-
helical peptides and zwitterionic-decorated lipoic acids (zw-LAs). Specific membrane …

Porphyrin dyes for nonlinear optical imaging of live cells

A Khadria, J Fleischhauer, I Boczarow, JD Wilkinson… - Iscience, 2018 - cell.com
Second harmonic generation (SHG)-based probes are useful for nonlinear optical imaging
of biological structures, such as the plasma membrane. Several amphiphilic porphyrin …

Optical recording of brain functions based on voltage-sensitive dyes

Q Yu, X Wang, L Nie - Chinese Chemical Letters, 2021 - Elsevier
To better understand the spatial distribution of brain functions, we need to monitor and
analyze neuronal activities. Electrophysiological technique has provided an important …

Combining voltage-sensitive dye, carbon fiber array, and extracellular nerve electrodes using a 3-D printed recording chamber and manipulators

CL Neveu, Y Huan, Y Momohara, PR Patel… - Journal of Neuroscience …, 2023 - Elsevier
Background The analyses of neuronal circuits require high-throughput technologies for
stimulating and recording many neurons simultaneously with single-neuron precision …

Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia

RM Costa, DA Baxter, JH Byrne - Communications Biology, 2022 - nature.com
Learning engages a high-dimensional neuronal population space spanning multiple brain
regions. However, it remains unknown whether it is possible to identify a low-dimensional …

Locally excited state–charge transfer state coupled dyes as optically responsive neuron firing probes

D Sirbu, JB Butcher, PG Waddell… - … A European Journal, 2017 - Wiley Online Library
A selection of NIR‐optically responsive neuron probes was produced comprising of a donor
julolidyl group connected to a BODIPY core and several different styryl and vinylpyridinyl …

Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies

N Aseyev, V Ivanova, P Balaban, E Nikitin - Biosensors, 2023 - mdpi.com
The optical imaging of neuronal activity with potentiometric probes has been credited with
being able to address key questions in neuroscience via the simultaneous recording of …