The chemical inhibitors of endocytosis: from mechanisms to potential clinical applications

OK Szewczyk-Roszczenko, P Roszczenko… - Cells, 2023 - mdpi.com
Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …

Role of clathrin and dynamin in clathrin mediated endocytosis/synaptic vesicle recycling and implications in neurological diseases

KL Prichard, NS O'Brien, SR Murcia… - Frontiers in Cellular …, 2022 - frontiersin.org
Endocytosis is a process essential to the health and well-being of cell. It is required for the
internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of …

α-Mangostin Promotes In Vitro and In Vivo Degradation of Androgen Receptor and AR-V7 Splice Variant in Prostate Cancer Cells

MC Nauman, JH Won, SM Petiwala, B Vemu, H Lee… - Cancers, 2023 - mdpi.com
Simple Summary Castration-resistant prostate cancer often develops in response to
continued drug treatment and is characterized by mutations in the androgen receptor …

2, 3-Dihydroquinazolin-4 (1 H)-ones and quinazolin-4 (3 H)-ones as broad-spectrum cytotoxic agents and their impact on tubulin polymerisation

NS O'Brien, J Gilbert, A McCluskey… - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Tubulin plays a central role in mitosis and has been the target of multiple anticancer drugs,
including paclitaxel. Herein two separate families of 2, 3-dihydroquinazoline-4 (1H)-ones …

Performance and photoresponse characterizations of pyrimidine quinolone carboxylate derivatives films-based heterojunction devices

AAM Farag, NAA Elkanzi, AH Ammar, N Roushdy - Optik, 2021 - Elsevier
In this investigation, novel pyrimido quinolone derivative carboxylate was produced. For the
first time, we attempted to obtain, a high-quality thin film of HBPQC using the thermal …

Synthesis, in vitro evaluation and molecular docking studies of novel naphthoisoxazolequinone carboxamide hybrids as potential antitumor agents

J Maldonado, W Acevedo, A Molinari… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Based on previous results with benzoindazolequinone (BIZQ) derivatives, a new series of
bioisosteric 3-methylnaphtho [2, 3-d] isoxazole-4, 9-quinones (NIQs), conjugated with C …

Bioinspired Synthesis of Pulvinic Acids Including Xerocomic Acid and Fluorescence Properties of Bis‐lactone Intermediates

É Pradayrol, B Séon‐Méniel, S Oger… - European Journal of …, 2023 - Wiley Online Library
A set of representative pulvinic acids were synthesised using a bioinspired strategy.
Terphenyl‐quinones (polyporic acid scaffold) were prepared via sequential Suzuki‐Miyaura …

[PDF][PDF] Investigation of 1, 4-Quinone Bioisosteres and the Synthesis of Bolinaquinone Analogues as Clathrin Inhibitors

NS O'Brien - 2023 - nova.newcastle.edu.au
These polygonic coats have been directly observed by negative staining. 4–6 Subsequent
studies isolated a secondary 100-110k Da adaptor protein that increased, but was not an …

[PDF][PDF] Xanthones from Mangosteen (Garcinia mangostana) Promote Androgen Receptor Degradation in Prostate Cancer

M NAUMAN - 2022 - indigo.uic.edu
The purple mangosteen contains numerous xanthones that have similar chemical cores but
vary in the orientation of functional groups. All xanthones contain a C6-C1-C6 ring structure …

[PDF][PDF] Library and Information Science in the Era of Network: Challenge, Reform and Innovation

J Bao - International Journal of Frontiers in Sociology, 2021 - francis-press.com
With the continuous development of network technology, network technology has been
applied to various fields of social life and production. The development of Library and …