An overview of cancer health disparities: new approaches and insights and why they matter

TZ Minas, M Kiely, A Ajao, S Ambs - Carcinogenesis, 2021 - academic.oup.com
Cancer health disparities remain stubbornly entrenched in the US health care system. The
Affordable Care Act was legislation to target these disparities in health outcomes. Expanded …

Genetic and biological drivers of prostate cancer disparities in Black men

J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics

D Lowder, K Rizwan, C McColl, A Paparella, M Ittmann… - Cancer letters, 2022 - Elsevier
The largest US cancer health disparity exists in prostate cancer, with Black men having more
than a two-fold increased risk of dying from prostate cancer compared to all other races. This …

Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers

T Gong, W Jaratlerdsiri, J Jiang, C Willet, T Chew… - Genome medicine, 2022 - Springer
Background African ancestry is a significant risk factor for advanced prostate cancer (PCa).
Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the …

A review of cancer genetics and genomics studies in Africa

SO Rotimi, OA Rotimi, B Salhia - Frontiers in oncology, 2021 - frontiersin.org
Cancer is the second leading cause of death globally and is projected to overtake infectious
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …

Cancer in Africa: is it a genetic or environmental health problem?

AA Bahnassy, MS Abdellateif, ARN Zekri - Frontiers in Oncology, 2020 - frontiersin.org
Patients of African ancestry have the poorest outcome and the shortest survival rates from
cancer globally. This could be attributed to many variables including racial, biological …

Genetic contributions to prostate cancer disparities in men of West African descent

JR Johnson, L Woods-Burnham, SE Hooker Jr… - Frontiers in …, 2021 - frontiersin.org
Prostate cancer (PCa) is the second most frequently diagnosed malignancy and the second
leading cause of death in men worldwide, after adjusting for age. According to the …

Experimental challenges to modeling prostate cancer heterogeneity

T del NJ Flores-Téllez, E Baena - Cancer Letters, 2022 - Elsevier
Tumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection,
relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous …

Clinical biofluid assays for prostate cancer

T Borbiev, I Kohaar, G Petrovics - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer (PCa) is the most frequent malignancy, and the second
leading cause of cancer-related death, in men in the United States. PCa detection has been …

Acquired copy number variation in prostate tumours: a review of common somatic copy number alterations, how they are formed and their clinical utility

DE O'Malley, K Raspin, PE Melton, KP Burdon… - British Journal of …, 2024 - nature.com
Prostate cancer is one of the most commonly diagnosed cancers in men and unfortunately,
disease will progress in up to a third of patients despite primary treatment. Currently, there is …