Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors
that regulate lipid and energy metabolism. The brain–gut–liver axis plays an essential role in …

Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was
identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats …

Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain
bile acid homeostasis, which is essential for protecting liver and other tissues and cells from …

Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and
increased serum bile acid concentrations, is associated with increased rates of stillbirth …

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …

Obesity has become more prevalent in most developed countries over the past few decades,
and is increasingly recognized as a major risk factor for several common types of cancer. As …

Cholestasis is an impairment of bile formation/flow at the level of the hepatocyte and/or
cholangiocyte. The first, and for the moment, most established medical treatment is the …

Background & Aims The clinical efficacy of ursodeoxycholic acid (UDCA) in primary biliary
cholangitis (PBC) remains subject to debate as definitive randomized controlled trials are …