Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard
clinical treatment includes chemotherapy, surgical therapy, and radiation therapy …

Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …

The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …

Many DNA-hypermethylated cancer genes are occupied by the Polycomb (PcG) repressor
complex in embryonic stem cells (ESCs). Their prevalence in the full spectrum of cancers …

Bone cancer including primary bone cancer and metastatic bone cancer, remains a
challenge claiming millions of lives and affecting the life quality of survivors. Conventional …

We previously demonstrated that human mesenchymal stem cells (MSCs) promote the
growth of osteosarcoma in the bone microenvironment. The aim of the present study was to …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

Osteosarcoma is the most common type of bone cancer, especially in children and young
adults. The primary treatment for osteosarcoma is a combination of surgery and …

Osteosarcoma is the most common primary bone tumor in children and adolescents and is
typically associated with a poor prognosis. Tumor stem cells (TSCs) are presumed to drive …

Background Over the last two or three decades, the pace of development of treatments for
osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still …