With the recognition in the 1960s and 1970s of the periodontopathic importance of the
microbial biofilm and its specific anaerobic microorganisms, periodontitis was treated as an …

The concept of focal infection or systemic disease arising from infection of the teeth was
generally accepted until the mid‐20th century when it was dismissed because of lack of …

Seroepidemiology, pathology, and animal studies provide evidence for a possible
association between Chlamydia pneumoniae infections and atherosclerosis, coronary heart …

Objective To investigate the risk of incident myocardial infarction, congestive heart failure,
and all cause mortality associated with prescription of oral antidiabetes drugs. Design …

Background—Inflammatory processes have fundamental roles in stroke in both the etiology
of ischemic cerebrovascular disease and the pathophysiology of cerebral ischemia. We …

In recent years, the frequency of serious cardiovascular infections such as endocarditis has
increased, particularly in association with nosocomially acquired antibiotic-resistant …

Background—Matrix metalloproteinases are best recognized for their ability to degrade the
extracellular matrix in both physiological and pathological conditions. However, recent …

Background—Matrix metalloproteinases (MMPs) contribute to collagen degradation and
remodeling of the extracellular matrix after myocardial infarction; however, their role in …

Background Drug repositioning offers the possibility of faster development times and
reduced risks in drug discovery. With the rapid development of high-throughput technologies …

Survey evidence through the early 1990s generally suggests a reduction in disability in the
elderly population of the United States. Because the evidence is not fully consistent, several …