Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Loss of fertility is a major concern for female reproductive-age cancer survivors, since a
common side-effect of conventional cytotoxic cancer therapies is permanent damage to the …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

Ovarian age is classically considered the main cause of female reproductive infertility. In
women, the process proceeds as an ongoing decline in the primordial follicle stockpile and it …

Endometriosis is a common disorder associated with pain, gastrointestinal and urinary
symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions …

The immune system plays a major role in maintaining many physiological processes in the
reproductive system. However, a complete characterization of the immune milieu in the …

In mammals, ovarian function is dependent on the primordial follicle pool and the rate of
primordial follicle activation determines a female's reproductive lifespan. Ovarian ageing is …