Long noncoding RNAs (lncRNAs) are a relatively poorly understood class of RNAs with little
or no coding capacity transcribed from a set of incompletely annotated genes. They have …

Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …

The phenomenon of RNA interference (RNAi) which involves sequence-specific gene
regulation by small non-coding RNAs, ie, small interfering RNA (siRNA) and microRNA …

Osteoporosis is a common disorder, affecting hundreds of millions of people worldwide, and
characterized by decreased bone mineral density and increased fracture risk. Known …

Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …

microRNAs (miRNAs) are non coding RNAs with different biological functions and
pathological implications. Given their role as post-transcriptional gene expression …

The phenomenon of RNA interference (RNAi) is involved in sequence-specific gene
regulation driven by the introduction of dsRNA resulting in inhibition of translation or …

Cancer and organ injury—such as that occurring in the perioperative period, including acute
lung injury, myocardial infarction, and acute gut injury—are among the leading causes of …

The human genome is 'pervasively transcribed'leading to a complex array of non-coding
RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in …

Genome editing tools have the potential to change the genomic architecture of a genome at
precise locations, with desired accuracy. These tools have been efficiently used for trait …