Numerous proteins are involved in the multiple pathways of the DNA damage response
network and play a key role to protect the genome from the wide variety of damages that can …

Organismal aging involves the progressive decline in organ function and increased
susceptibility to age-associated diseases. Regardless of its origin, cellular aging is …

Background The immunosuppressive microenvironment of lung cancer serves as an
important endogenous contributor to treatment failure. The present study aimed to …

Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple
species. We have recently shown that DR in progeroid DNA repair‐deficient mice …

Non-esterified fatty acids (NEFAs) promote de novo lipogenesis, which caused abnormal
hepatic lipid accumulation, by the NFκB–Orai1 pathway. Oxidative stress and endoplasmic …

Photodynamic therapy (PDT) is a clinically approved cancer therapy of low invasiveness.
The therapeutic procedure involves administering a photosensitizing drug (PS), which is …

Human genetic syndromes deficient in nucleotide excision repair (NER), such as xeroderma
pigmentosum and Cockayne syndrome, may present neurological abnormalities and …

Efficient mechanisms for genomic maintenance (ie, DNA repair and DNA replication) are
crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic …

Nucleotide excision repair (NER) is a highly conserved mechanism to remove helix-
distorting DNA lesions. A major substrate for NER is DNA damage caused by environmental …

Karyomegalic interstitial nephritis (KIN) is a genetic adult-onset chronic kidney disease
(CKD) characterized by genomic instability and mitotic abnormalities in the tubular epithelial …