Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids) …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

This review describes the various manifestations of the pyrimidine system (alkylated,
glycosylated, benzo‐annelated.). These comprise pyrimidine nucleosides as well as …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Covering: 1985 to 2012 Diverse oxygenation patterns of natural products generated by
secondary metabolic pathways in microorganisms and plants are largely achieved through …

Covering: up to May 2006. This Highlight provides an overview of the molecular logic
employed in the formation and elaboration of pyrroles during natural product biosyntheses …

Natural products biosynthesized wholly or in part by nonribosomal peptide synthetases
(NRPSs) are some of the most important drugs currently used clinically for the treatment of a …