Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum

PCM Van Zijl, WW Lam, J Xu, L Knutsson, GJ Stanisz - Neuroimage, 2018 - Elsevier
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

The relayed nuclear Overhauser effect in magnetization transfer and chemical exchange saturation transfer MRI

Y Zhou, C Bie, PCM van Zijl, NN Yadav - NMR in biomedicine, 2023 - Wiley Online Library
Magnetic resonance (MR) is a powerful technique for noninvasively probing molecular
species in vivo but suffers from low signal sensitivity. Saturation transfer (ST) MRI …

Accuracy in the quantification of chemical exchange saturation transfer (CEST) and relayed nuclear Overhauser enhancement (rNOE) saturation transfer effects

XY Zhang, F Wang, H Li, J Xu, DF Gochberg… - NMR in …, 2017 - Wiley Online Library
Accurate quantification of chemical exchange saturation transfer (CEST) effects, including
dipole–dipole mediated relayed nuclear Overhauser enhancement (rNOE) saturation …

A new NOE-mediated MT signal at around− 1.6 ppm for detecting ischemic stroke in rat brain

XY Zhang, F Wang, A Afzal, J Xu, JC Gore… - Magnetic resonance …, 2016 - Elsevier
In the present work, we reported a new nuclear Overhauser enhancement (NOE)-mediated
magnetization transfer (MT) signal at around− 1.6 ppm (NOE (− 1.6)) in rat brain and …

Whole‐brain amide CEST imaging at 3T with a steady‐state radial MRI acquisition

R Sui, L Chen, Y Li, J Huang, KWY Chan… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To develop a steady‐state saturation with radial readout chemical exchange
saturation transfer (starCEST) for acquiring CEST images at 3 Tesla (T). The polynomial …

Investigation of the contribution of total creatine to the CEST Z‐spectrum of brain using a knockout mouse model

L Chen, H Zeng, X Xu, NN Yadav, S Cai… - NMR in …, 2017 - Wiley Online Library
The current study aims to assign and estimate the total creatine (tCr) signal contribution to
the Z‐spectrum in mouse brain at 11.7 T. Creatine (Cr), phosphocreatine (PCr) and protein …

Protein aggregation linked to Alzheimer's disease revealed by saturation transfer MRI

L Chen, Z Wei, KWY Chan, S Cai, G Liu, H Lu… - Neuroimage, 2019 - Elsevier
The goal of this study was to develop a molecular biomarker for the detection of protein
aggregation involved in Alzheimer's disease (AD) by exploiting the features of the water …

Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues

J Xu, JJ Chung, T Jin - NMR in Biomedicine, 2023 - Wiley Online Library
Chemical exchange saturation transfer (CEST) MRI has become a promising technique to
assay target proteins and metabolites through their exchangeable protons, noninvasively …

Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer's disease at 3 T

J Huang, JHC Lai, KH Tse, GWY Cheng… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To optimize and apply deep neural network based CEST (deepCEST) and
apparent exchange dependent‐relaxation (deepAREX) for imaging the mouse brain with …

Mapping tissue pH in an experimental model of acute stroke–Determination of graded regional tissue pH changes with non-invasive quantitative amide proton transfer …

E Wang, Y Wu, JS Cheung, T Igarashi, L Wu, X Zhang… - Neuroimage, 2019 - Elsevier
Abstract pH-weighted amide proton transfer (APT) MRI is sensitive to tissue pH change
during acute ischemia, complementing conventional perfusion and diffusion stroke imaging …