Fanconi anaemia and cancer: an intricate relationship
G Nalepa, DW Clapp - Nature Reviews Cancer, 2018 - nature.com
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
SUMO conjugation–a mechanistic view
A Pichler, C Fatouros, H Lee, N Eisenhardt - Biomolecular concepts, 2017 - degruyter.com
The regulation of protein fate by modification with the small ubiquitin-related modifier
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …
(SUMO) plays an essential and crucial role in most cellular pathways. Sumoylation is highly …
RNA transcripts stimulate homologous recombination by forming DR-loops
Homologous recombination (HR) repairs DNA double-strand breaks (DSBs) in the S and G2
phases of the cell cycle,–. Several HR proteins are preferentially recruited to DSBs at …
phases of the cell cycle,–. Several HR proteins are preferentially recruited to DSBs at …
Spatiotemporal regulation of posttranslational modifications in the DNA damage response
NP Dantuma, H van Attikum - The EMBO journal, 2016 - embopress.org
A timely and accurate cellular response to DNA damage requires tight regulation of the
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …
Control of structure-specific endonucleases to maintain genome stability
PM Dehé, PHL Gaillard - Nature reviews Molecular cell biology, 2017 - nature.com
Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …
recombination and repair, and emerging roles in transcription. These enzymes have …
Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics
M Bogliolo, J Surralles - Current opinion in genetics & development, 2015 - Elsevier
Fanconi anemia (FA) is characterized by bone marrow failure, malformations, and
chromosome fragility. We review the recent discovery of FA genes and efforts to develop …
chromosome fragility. We review the recent discovery of FA genes and efforts to develop …
ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy
The mismatch repair (MMR) deficiency of cancer cells drives mutagenesis and offers a
useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not …
useful biomarker for immunotherapy. However, many MMR-deficient (MMR-d) tumors do not …
[HTML][HTML] TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
R Rai, Y Chen, M Lei, S Chang - Nature communications, 2016 - nature.com
Abstract Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting
protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays …
protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays …
SUMO-mediated regulation of DNA damage repair and responses
P Sarangi, X Zhao - Trends in biochemical sciences, 2015 - cell.com
Sumoylation has important roles during DNA damage repair and responses. Recent broad-
scope and substrate-based studies have shed light on the regulation and significance of …
scope and substrate-based studies have shed light on the regulation and significance of …
The functional roles of PML nuclear bodies in genome maintenance
HR Chang, A Munkhjargal, MJ Kim, SY Park… - Mutation Research …, 2018 - Elsevier
In the nucleus, there are several membraneless structures called nuclear bodies. Among
them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome …
them, promyelocytic leukemia nuclear bodies (PML-NBs) are involved in multiple genome …