[HTML][HTML] Revisiting tuberculosis screening: An insight to complementary diagnosis and prospective molecular approaches for the recognition of the dormant TB …

AH Alvarez - Microbiological Research, 2021 - Elsevier
Tuberculosis (TB) is defined as a chronic infection in both human and cattle hosts and many
subclinical cases remain undetected. After the pathogen is inhaled by a host, phagocyted …

Genome-edited livestock to secure sustainability

T Sonstegard, J Bostrom, K Martins… - Reproduction …, 2024 - CSIRO Publishing
Context. Sustainable improvement of production in most tropical dairy systems is a
significant challenge, because the cattle breeds with the most genetic potential for milk …

Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection

WJ Brewer, AM Xet-Mull, A Yu, MI Sweeney… - Cell reports, 2022 - cell.com
During mycobacterial infections, pathogenic mycobacteria manipulate both host immune
and stromal cells to establish and maintain a productive infection. In humans, non-human …

Preferential differential gene expression within the WC1.1+ γδ T cell compartment in cattle naturally infected with Mycobacterium bovis

SA Bhat, M Elnaggar, TJ Hall, GP McHugo… - Frontiers in …, 2023 - frontiersin.org
Bovine tuberculosis (bTB), caused by infection with Mycobacterium bovis, continues to
cause significant issues for the global agriculture industry as well as for human health. An …

Integrative genomics analysis highlights functionally relevant genes for equine behaviour

AR Holtby, TJ Hall, BA McGivney, H Han… - Animal …, 2023 - Wiley Online Library
Behavioural plasticity enables horses entering an exercise training programme to adapt with
reduced stress. We characterised SNPs associated with behaviour in yearling …

In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying Mycobacterium bovis infection

A Hasankhani, A Bahrami, S Mackie… - Frontiers in …, 2022 - frontiersin.org
Objective Bovine tuberculosis (bTB) is a chronic respiratory infectious disease of domestic
livestock caused by intracellular Mycobacterium bovis infection, which causes~ $3 billion in …

[HTML][HTML] Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens

TJ Hall, GP McHugo, MP Mullen, JA Ward, KE Killick… - Tuberculosis, 2024 - Elsevier
Mycobacterium tuberculosis, the causative agent of human tuberculosis (hTB), is a close
evolutionary relative of Mycobacterium bovis, which causes bovine tuberculosis (bTB), one …

Common protein-coding variants influence the racing phenotype in galloping racehorse breeds

H Han, BA McGivney, L Allen, D Bai, LR Corduff… - Communications …, 2022 - nature.com
Selection for system-wide morphological, physiological, and metabolic adaptations has led
to extreme athletic phenotypes among geographically diverse horse breeds. Here, we …

Phenotype of bovine mononuclear phagocytes–An update

SC Talker, JC Hope, A Summerfield - Veterinary Immunology and …, 2024 - Elsevier
Studying mononuclear phagocytes by flow cytometry is challenging due to their phenotypic
similarities and the high plasticity of monocytic cells. Despite these challenges, significant …

Integrative genomics sheds light on the immunobiology of tuberculosis in cattle

JF O'Grady, GP McHugo, JA Ward, TJ Hall… - bioRxiv, 2024 - biorxiv.org
Mycobacterium bovis causes bovine tuberculosis (bTB), an infectious disease of cattle that
poses a zoonotic threat to humans. Research has shown that bTB susceptibility is a …