Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
[HTML][HTML] Assessing skin sensitization hazard in mice and men using non-animal test methods
D Urbisch, A Mehling, K Guth, T Ramirez… - Regulatory Toxicology …, 2015 - Elsevier
Sensitization, the prerequisite event in the development of allergic contact dermatitis, is a
key parameter in both hazard and risk assessments. The pathways involved have recently …
key parameter in both hazard and risk assessments. The pathways involved have recently …
[HTML][HTML] Probabilistic risk assessment–the keystone for the future of toxicology
Safety sciences must cope with uncertainty of models and results as well as information
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
gaps. Acknowledging this uncertainty necessitates embracing probabilities and accepting …
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
NC Kleinstreuer, S Hoffmann, N Alépée… - Critical reviews in …, 2018 - Taylor & Francis
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic
understanding and concurrent necessity for non-animal testing approaches have evolved to …
understanding and concurrent necessity for non-animal testing approaches have evolved to …
[HTML][HTML] From the exposome to mechanistic understanding of chemical-induced adverse effects
The exposome encompasses an individual's exposure to exogenous chemicals, as well as
endogenous chemicals that are produced or altered in response to external stressors. While …
endogenous chemicals that are produced or altered in response to external stressors. While …
[HTML][HTML] Using Machine Learning to make nanomaterials sustainable
JJ Scott-Fordsmand, MJB Amorim - Science of The Total Environment, 2023 - Elsevier
Sustainable development is a key challenge for contemporary human societies; failure to
achieve sustainability could threaten human survival. In this review article, we illustrate how …
achieve sustainability could threaten human survival. In this review article, we illustrate how …
[HTML][HTML] Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their …
M Aschner, S Ceccatelli, M Daneshian, E Fritsche… - Altex, 2017 - ncbi.nlm.nih.gov
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
BZ Schmidt, M Lehmann, S Gutbier, E Nembo… - Archives of …, 2017 - Springer
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …
assessment. Since the interpretation of animal data and their extrapolation to man is …
[HTML][HTML] Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology
C Rovida, T Barton-Maclaren, E Benfenati, F Caloni… - Altex, 2020 - ncbi.nlm.nih.gov
Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …
substance for which there is a toxicological data gap. The OECD is working on case studies …