Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …

Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Thioredoxin system is a ubiquitous disulfide reductase system evolutionarily conserved
through all living organisms. It contains thioredoxin (Trx), thioredoxin reductase (TrxR) and …

Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …

Ethnopharmacological relevance The leaves of Allophylus edulis (A. St.-Hil., A. Juss. &
Cambess.) Radlk.(Sapindaceae) are traditionally used as a natural anti-inflammatory agent; …

Since the last 4 decades, Bedaquiline has been the first drug discovered as a new kind of
anti-tubercular agent and received FDA approval in December 2012 to treat pulmonary multi …

Tubercular uveitis (TB-uveitis) remains a conundrum in the uveitis field, which is mainly
related to the diverse clinical phenotypes of TB-uveitis. Moreover, it remains difficult to …

Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional
tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies …

In 2019 10 million people developed symptomatic tuberculosis (TB) disease and 1.2 million
died. In active TB the inflammatory response causes tissue destruction, which leads to both …