5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …
thiazolidinones being a widely studied class of small molecules used in modern organic and …
Recent developments with rhodanine as a scaffold for drug discovery
D Kaminskyy, A Kryshchyshyn… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …
privileged heterocycles in medicinal chemistry. The main achievements include the …
Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry
T Mendgen, C Steuer, CD Klein - Journal of medicinal chemistry, 2012 - ACS Publications
Rhodanines and related five-membered heterocycles with multiple heteroatoms have
recently gained a reputation of being unselective compounds that appear as “frequent …
recently gained a reputation of being unselective compounds that appear as “frequent …
[HTML][HTML] Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)
AKD bin Ahmad Kamar, LJ Yin, CT Liang… - Medicine in Drug …, 2022 - Elsevier
Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin.
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …
Toward the discovery of novel anti‐HIV drugs. Second‐generation inhibitors of the cellular ATPase DDX3 with improved anti‐HIV activity: Synthesis, structure–activity …
A hit optimization protocol applied to the first nonnucleoside inhibitor of the ATPase activity
of human DEAD‐box RNA helicase DDX3 led to the design and synthesis of second …
of human DEAD‐box RNA helicase DDX3 led to the design and synthesis of second …
Privileged scaffold decoration for the identification of the first trisubstituted triazine with anti-SARS-CoV-2 Activity
S Cesarini, I Vicenti, F Poggialini, M Secchi… - Molecules, 2022 - mdpi.com
Current therapy against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-
2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified …
2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified …
Base-Promoted Formal [3+ 2] Cycloaddition of α-Halohydroxamates with Carbon Disulfide to Synthesize Polysubstituted Rhodanines
X Lei, J Feng, Q Guo, C Xu, J Shi - Organic Letters, 2022 - ACS Publications
A concise and practical strategy via potassium-carbonate-mediated [3+ 2]-cycloaddition
reaction of α-halohydroxamates with the common solvent carbon disulfide for the synthesis …
reaction of α-halohydroxamates with the common solvent carbon disulfide for the synthesis …
Catalyst-and additive-free syntheses of rhodanine and S-alkyl dithiocarbamate derivatives from sulfoxonium ylides
An efficient catalyst-and additive-free facile access to rhodanine and S-alkyl dithiocarbamate
derivatives via multi-component reaction of amines, CS2 and α-ester sulfoxonium ylides in …
derivatives via multi-component reaction of amines, CS2 and α-ester sulfoxonium ylides in …
Synthesis and biological evaluation of new rhodanine analogues bearing 2-chloroquinoline and benzo [h] quinoline scaffolds as anticancer agents
Abstract Several rhodanine derivatives (9–39) were synthesized for evaluation of their
potential as anticancer agents. Villsmeier cyclization to synthesize aza-aromatic aldehydes …
potential as anticancer agents. Villsmeier cyclization to synthesize aza-aromatic aldehydes …
Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound
M Tarleton, J Gilbert, MJ Robertson, A McCluskey… - …, 2011 - pubs.rsc.org
In our efforts to prevent highly toxic compounds progressing through our anti-parasitic drug
development program, we serendipitously discovered a family of 2-phenylacrylonitriles with …
development program, we serendipitously discovered a family of 2-phenylacrylonitriles with …