Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - ASPET
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Biochemical and biological attributes of matrix metalloproteinases
N Cui, M Hu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
involved in the degradation of various proteins in the extracellular matrix (ECM). Typically …
[HTML][HTML] A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential
E Gobin, K Bagwell, J Wagner, D Mysona… - BMC cancer, 2019 - Springer
Abstract Implication By understanding Matrix Metalloprotease (MMP) dysregulation from a
pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across …
pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across …
The role of matrix metalloproteinases in the epithelial‐mesenchymal transition of hepatocellular carcinoma
C Scheau, IA Badarau, R Costache… - Analytical cellular …, 2019 - Wiley Online Library
The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
local and distant progression of many malignant tumors, including hepatocellular carcinoma …
[HTML][HTML] Membrane-type matrix metalloproteinases: Their functions and regulations
Y Itoh - Matrix Biology, 2015 - Elsevier
Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
Matrix metalloproteinases in inflammation
L Nissinen, VM Kähäri - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Abstract Background Matrix metalloproteinases (MMPs) are a family of ubiquitously
expressed zinc-dependent endopeptidases with broad substrate specificity and strictly …
expressed zinc-dependent endopeptidases with broad substrate specificity and strictly …
[HTML][HTML] Physiology and pathophysiology of matrix metalloproteases
T Klein, R Bischoff - Amino acids, 2011 - Springer
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …
based on a conserved mechanism involving activation of an active site-bound water …
[HTML][HTML] Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models
M Fanjul-Fernández, AR Folgueras, S Cabrera… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …
important roles in multiple physiological and pathological processes. These enzymes are …
[HTML][HTML] Integrated multi-omics investigations of metalloproteinases in colon cancer: Focus on MMP2 and MMP9
M Buttacavoli, G Di Cara, E Roz… - International journal of …, 2021 - mdpi.com
Colorectal cancer (CRC) develops by genetic and epigenetic alterations. However, the
molecular mechanisms underlying metastatic dissemination remain unclear and could …
molecular mechanisms underlying metastatic dissemination remain unclear and could …
Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections
JN Kay, I De la Huerta, IJ Kim, Y Zhang… - Journal of …, 2011 - Soc Neuroscience
The retina contains ganglion cells (RGCs) that respond selectively to objects moving in
particular directions. Individual members of a group of ON-OFF direction-selective RGCs …
particular directions. Individual members of a group of ON-OFF direction-selective RGCs …