The prenylated flavonoid icaritin (ICT) is currently undergoing phase 3 clinical trial for the
treatment of advanced hepatocellular carcinoma (HCC), based on a solid array of preclinical …

This review focuses on the conventional treatment, signaling pathways and various reasons
for drug resistance with an understanding of novel methods that can lead to effective …

Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important
cause of treatment failure for many cancer types and represents an unmet clinical need …

Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as
a kind of phytoestrogen and has been proven to be effective for the treatment of …

Cancer cells exhibit molecular characteristics that confer them different proliferative
capacities and survival advantages to adapt to stress conditions, such as deregulation of …

Estrogen nuclear receptors, represented by the canonical forms ERα66 and ERβ1, are the
main mediators of the estrogen-dependent pathophysiology in mammals. However …

Cell migration–inducing protein (CEMIP), also known as KIAA1199 and hyaluronan-binding
protein involved in hyaluronan depolymerization, is a new member of the hyaluronidase …

Osteosarcoma (OS) is the most common type of primary malignant tumors that originate in
the bone. Resistance to chemotherapy confers a poor prognosis on OS patients …

Cisplatin is a platinum-based chemotherapeutic drug used in the standard treatment of
various solid cancers including testicular, bladder, head and neck, cervical and ovarian …

For patients with esophageal squamous cell carcinoma (ESCC), standard therapeutic
methods (cisplatin and radiotherapy) have been found to be ineffective and severely toxic …