Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm

TA Quinn, P Kohl - Physiological reviews, 2021 - journals.physiology.org
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

[HTML][HTML] Structure and function of the ventricular tachycardia isthmus

EJ Ciaccio, E Anter, J Coromilas, EY Wan… - Heart Rhythm, 2022 - Elsevier
Highlights•Postinfarction ventricular tachycardia (VT) caused by a reentrant circuit is an
important clinical problem.•Catheter ablation may not prevent VT because of difficulty in …

Tunable human myocardium derived decellularized extracellular matrix for 3D bioprinting and cardiac tissue engineering

G Basara, SG Ozcebe, BW Ellis, P Zorlutuna - Gels, 2021 - mdpi.com
The generation of 3D tissue constructs with multiple cell types and matching mechanical
properties remains a challenge in cardiac tissue engineering. Recently, 3D bioprinting has …

MedalCare-XL: 16,900 healthy and pathological synthetic 12 lead ECGs from electrophysiological simulations

K Gillette, MAF Gsell, C Nagel, J Bender, B Winkler… - Scientific Data, 2023 - nature.com
Mechanistic cardiac electrophysiology models allow for personalized simulations of the
electrical activity in the heart and the ensuing electrocardiogram (ECG) on the body surface …

Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia

A Lopez-Perez, R Sebastian, M Izquierdo… - Frontiers in …, 2019 - frontiersin.org
In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …

Biowire model of interstitial and focal cardiac fibrosis

EY Wang, N Rafatian, Y Zhao, A Lee, BFL Lai… - ACS central …, 2019 - ACS Publications
Myocardial fibrosis is a severe global health problem due to its prevalence in all forms of
cardiac diseases and direct role in causing heart failure. The discovery of efficient antifibrotic …

Predicting risk of sudden cardiac death in patients with cardiac sarcoidosis using multimodality imaging and personalized heart modeling in a multivariable classifier

JK Shade, A Prakosa, DM Popescu, R Yu… - Science …, 2021 - science.org
Cardiac sarcoidosis (CS), an inflammatory disease characterized by formation of
granulomas in the heart, is associated with high risk of sudden cardiac death (SCD) from …

Air pollution and cardiac arrhythmias: from epidemiological and clinical evidences to cellular electrophysiological mechanisms

S Zhang, W Lu, Z Wei, H Zhang - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
Cardiovascular disease is the leading cause of death worldwide and kills over 17 million
people per year. In the recent decade, growing epidemiological evidence links air pollution …

From evidence-based medicine to digital twin technology for predicting ventricular tachycardia in ischaemic cardiomyopathy

AGW de Lepper, CMA Buck… - Journal of the …, 2022 - royalsocietypublishing.org
Survivors of myocardial infarction are at risk of life-threatening ventricular tachycardias (VTs)
later in their lives. Current guidelines for implantable cardioverter defibrillators (ICDs) …

A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient

ML Rexius-Hall, NN Khalil, SS Escopete, X Li, J Hu… - Science …, 2022 - science.org
After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …