Sickle cell disease is a very variable condition, with outcomes ranging from death in
childhood to living relatively symptom free into the 8 th decade. Much of this variability is …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Abstract α‐Thalassemia is one of the most important genetic modulators of sickle cell
disease (SCD). Both beneficial and detrimental effects have been described previously. We …

Studies of genetic variants and their associations with disease outcomes using recent
molecular technology advances and the broad variety of statistical methodologies available …

Sickle cell disease (SCD) is characterized by variable clinical outcomes, with some patients
suffering life-threatening complications during childhood, and others living relatively …

The loss of red blood cell (RBC) deformability in sickle cell anaemia (SCA) is considered the
primary factor responsible for episodes of acute pain and downstream progressive organ …

Sickle cell disease (SCD) clinically manifests itself with a myriad of complications. Stroke,
both ischemic and hemorrhagic, as well as silent white matter changes, occurs at a relatively …

G6PD 0 11 4 0 2 1 0 0 gHbF N/A 2.718 2.135 2.137 2.1777 2.144 N/AN/A (1.89-2.62)(1.89-
2.69)(1.89-2.49)(1.89-2.49)(1.89-2.32) α-thalassemic N/A 131 αα/αα, 39 αα/αα, 31 αα/αα, 62 …

Sickle cell anemia (SCA) is the most common cause of stroke in children. As it is a rare
disease, studies investigating the association with complications like stroke in SCD have …

Background: Sickle cell disease (SCD) is the commonest cause of stroke in children. As it is
a rare disease, studies investigating the association with complications like stroke in SCD …