The highly structurally similar drugs flupirtine and retigabine have been regarded as safe
and effective for many years but lately they turned out to exert intolerable side effects. While …

Recent advances in the field of cellular reprogramming have opened a route to studying the
fundamental mechanisms underlying common neurological disorders. High‐density …

Rosin, a natural resin obtained from conifer trees, has a long history of use in traditional folk
medicine for treating abscesses, wounds, carbuncles, and burns, etc. It has been employed …

Aim Atrial fibrillation is the most common persistent cardiac arrhythmia, and it is not well
controlled by present drugs. Because some resin acids open voltage‐gated potassium …

Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly
improved selectivity for Kv7. 2/Kv7. 3 over related potassium channels, ie, Kv7. 3/Kv7. 5 …

Voltage-gated ion channels are the molecular determinants of cellular excitability. This
group of ion channels is one of the most important pharmacological targets in excitable …

Thalamic hemorrhage can lead to the development of central post-stroke pain. Changes in
histone acetylation levels, which are regulated by histone deacetylases, affect the excitability …

Tinnitus is a widespread public health issue that imposes a significant social burden. The
occurrence and maintenance of tinnitus have been shown to be associated with abnormal …

Tinnitus, the perception of sound in the absence of a corresponding sound source is a
frequent disorder. Many pharmacological compounds have been investigated, but for none …

Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was
recently shown to open voltage-gated potassium (KV) channels. The hydrophobic part of …