The application of metal compounds in the medical field dates back to the XVI century with
some isolated reports about the therapeutic importance of metals and their compounds in …

Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

Gallium, group IIIa metal, shares certain chemical characteristics with iron which enable it to
function as an iron mimetic that can disrupt iron-dependent tumor cell growth. Gallium may …

Skeletal muscle atrophy is associated with a loss of muscle protein which may result from
both increased proteolysis and decreased protein synthesis. Investigations on cell signaling …

Gold alkynyl complexes with phosphane ligands of the type (alkynyl) Au (I)(phosphane)
represent a group of bioorganometallics, which has only recently been evaluated …

7. SUMMARY AND OUTLOOK 296 ACKNOWLEDGMENTS 297 ABBREVIATIONS 297
REFERENCES 297 Abstract: Clinical trials have shown gallium nitrate, a group 13 (formerly …

Abstract Tris-(8-quinolinolato) gallium (III)(KP46, AP-002) is an orally administered
investigational anticancer and bone-protective drug currently being evaluated in patients …

Background Hypoxic and necrotic regions that accrue within solid tumors in vivo are known
to be associated with metastasis formation, radio-and chemotherapy resistance, and drug …

Evidence for reduced expression of cyclin G associated kinase (GAK) in glomeruli of
patients with chronic kidney disease was observed in the Nephroseq human database, and …

Background Osteosarcoma is the most frequent primary malignant bone tumor. Although
survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with …