Efferocytosis in health and disease
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …
Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
G Hajishengallis, T Chavakis… - Periodontology 2000, 2020 - Wiley Online Library
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …
IL-17 receptor–based signaling and implications for disease
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …
Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later
G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …
types of myeloid cells and lymphocytes involved in the initiation and progression of …
DEL-1 promotes macrophage efferocytosis and clearance of inflammation
Resolution of inflammation is essential for tissue homeostasis and represents a promising
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 …
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 …
The role of the host—Neutrophil biology
ILC Chapple, J Hirschfeld, A Kantarci… - Periodontology …, 2023 - Wiley Online Library
Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …
New developments in neutrophil biology and periodontitis
G Hajishengallis - Periodontology 2000, 2020 - Wiley Online Library
Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …
but are now appreciated as functionally versatile cells with critical roles in chronic …
The periodontal war: microbes and immunity
JL Ebersole, D Dawson III, P Emecen‐Huja… - Periodontology …, 2017 - Wiley Online Library
Maintenance of periodontal health or transition to a periodontal lesion reflects the
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …
Resolution of acute inflammation and the role of resolvins in immunity, thrombosis, and vascular biology
BE Sansbury, M Spite - Circulation research, 2016 - Am Heart Assoc
Acute inflammation is a host-protective response that is mounted in response to tissue injury
and infection. Initiated and perpetuated by exogenous and endogenous mediators, acute …
and infection. Initiated and perpetuated by exogenous and endogenous mediators, acute …
Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy
Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …