Efferocytosis in health and disease

AC Doran, A Yurdagul Jr, I Tabas - Nature Reviews Immunology, 2020 - nature.com
The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

G Hajishengallis, T Chavakis… - Periodontology 2000, 2020 - Wiley Online Library
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

IL-17 receptor–based signaling and implications for disease

X Li, R Bechara, J Zhao, MJ McGeachy… - Nature immunology, 2019 - nature.com
IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes,
including host defense, tissue repair, the pathogenesis of inflammatory disease and the …

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

I Kourtzelis, X Li, I Mitroulis, D Grosser, T Kajikawa… - Nature …, 2019 - nature.com
Resolution of inflammation is essential for tissue homeostasis and represents a promising
approach to inflammatory disorders. Here we found that developmental endothelial locus-1 …

The role of the host—Neutrophil biology

ILC Chapple, J Hirschfeld, A Kantarci… - Periodontology …, 2023 - Wiley Online Library
Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with
lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial …

New developments in neutrophil biology and periodontitis

G Hajishengallis - Periodontology 2000, 2020 - Wiley Online Library
Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

The periodontal war: microbes and immunity

JL Ebersole, D Dawson III, P Emecen‐Huja… - Periodontology …, 2017 - Wiley Online Library
Maintenance of periodontal health or transition to a periodontal lesion reflects the
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …

Resolution of acute inflammation and the role of resolvins in immunity, thrombosis, and vascular biology

BE Sansbury, M Spite - Circulation research, 2016 - Am Heart Assoc
Acute inflammation is a host-protective response that is mounted in response to tissue injury
and infection. Initiated and perpetuated by exogenous and endogenous mediators, acute …

Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy

J Dort, Z Orfi, P Fabre, T Molina, TC Conte… - Nature …, 2021 - nature.com
Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …