Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Zinc-finger proteins in health and disease

M Cassandri, A Smirnov, F Novelli, C Pitolli… - Cell death …, 2017 - nature.com
Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …

Zinc-based biomaterials for regeneration and therapy

Y Su, I Cockerill, Y Wang, YX Qin, L Chang… - Trends in …, 2019 - cell.com
Zinc has been described as the 'calcium of the twenty-first century'. Zinc-based degradable
biomaterials have recently emerged thanks to their intrinsic physiological relevance …

Analysis of the role of the Hippo pathway in cancer

Y Han - Journal of translational medicine, 2019 - Springer
Cancer is a serious health issue in the world due to a large body of cancer-related human
deaths, and there is no current treatment available to efficiently treat the disease as the …

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

X Li, M Han, H Zhang, F Liu, Y Pan, J Zhu, Z Liao… - Biomarker …, 2022 - Springer
Zinc finger proteins are transcription factors with the finger domain, which plays a significant
role in gene regulation. As the largest family of transcription factors in the human genome …

[HTML][HTML] ISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response

LG De Sousa, K Rajapakshe, JR Canales… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The combination of ISA101, a human papilloma virus (HPV) 16 peptide
vaccine, and nivolumab showed a promising response rate of 33% in patients with incurable …

The complexity of TRIM28 contribution to cancer

P Czerwińska, S Mazurek, M Wiznerowicz - Journal of biomedical science, 2017 - Springer
Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular
biology has been extensively studied resulting in identification of a complex nature of …

SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways

X Ren, C Feng, Y Wang, P Chen, S Wang… - … & Molecular Medicine, 2023 - nature.com
Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters
and plays a key role in B-cell development. Previous studies have reported that its …

Zinc in cognitive impairment and aging

R Sun, J Wang, J Feng, B Cao - Biomolecules, 2022 - mdpi.com
Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …

ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression

G Wu, H Peng, M Tang, M Yang, J Wang, Y Hu, Z Li… - …, 2021 - thelancet.com
Background Resistance to platinum-based chemotherapy is a major cause of therapeutic
failure during the treatment of epithelial ovarian cancer (EOC) patients. Our study aims to …