Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …

Premature ovarian failure (POF) causing hypergonadotrophic hypogonadism occurs in 1%
of women. In majority of cases the underlying cause is not identified. The known causes …

We have isolated a series of genomic and cDNA clones mapping within the boundaries of
constitutional and tumor deletions that define the Wilms' tumor locus on human chromsome …

Based on the map location of the aniridia (AN) locus in human chromosomal band 11p13,
we have cloned a candidate AN cDNA (D11S812E) that is completely or partially deleted in …

Aniridia is a semidominant disorder in which development of the iris, lens, cornea and retina
is disturbed. The mouse mutation Small eye (Sey), which has been proposed as a model for …

Until relatively recently, the small number of identifiable inherited human diseases
associated with marked obesity were complex, pleiotropic developmental disorders, the …

We have recently described the isolation of a candidate for the Wilms' tumor susceptibility
gene mapping to band p13 of human chromosome 11. This gene, primarily expressed in …

WAGR syndrome is a rare genetic disorder characterized by a de novo deletion of 11p13
and is clinically associated with Wilms' tumor, aniridia, genitourinary anomalies, and mental …

Tumor formation arises as a consequence of alterations in the control of cell proliferation
and disorders in the interactions between ceils and their surroundings that result in invasion …

The BTG1 gene locus has been shown to be involved in at (8; 12)(q24; q22) chromosomal
translocation in a case of B‐cell chronic lymphocytic leukemia. We report here the cloning …